WHAT DOES TOTO 4D MEAN?

Aldosterone mediates its effects on electrolyte and renal homeostasis by binding into the MR receptors on principal epithelial cells within the renal cortical amassing duct. Sodium is reabsorbed through the ENaC (epithelial sodium channel) to the apical membranes of principal cells from the accumulating tubules. Aldosterone leads to amplified conc